HVH-2930, CAS 3034605-72-3

Product Description: HVH-2930 is an inhibitor for heat shock protein 90 (HSP90). HVH-2930 inhibits cell viability of BT474 (Trastuzumab (HY-P9907) sensitive) and JIMT-1 (Trastuzumab (HY-P9907) resistant), with IC50 of 6.86 μM and 4.42 μM, through downregulation of HSP90 clients HER2, p-HER2, AKT, p-AKT, cyclin D1 and survivin. HVH-2930 exhibits antitumor efficacy in mouse models. HVH-2930 exhibits good pharmacokinetic characteristics in mice[1].

Formula: C29H36N4O3

References: [1]La M T, et al. Discovery of Indazole Inhibitors for Heat Shock Protein 90 as Anti-Cancer Agents[J]. European Journal of Medicinal Chemistry, 2024: 116620.

CAS Number: 3034605-72-3

Molecular Weight: 488.62

Research Area: Cancer

Target: Akt;EGFR;HSP;Survivin

• SKU: MEXHY-161781-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-161781-0
• Package Unit: Get quote
• Quantity Unit: STK