KOR agonist 1

Product Description: KOR agonist 1 (Compound 7a) is a selective agonist for opioid receptor, with EC50s of 3.4, 701.2 and 1649 nM, for KOR, MOR and DOR, respectively. KOR agonist 1 binds KOR, MOR and DOR, with Kis of 3.9, 1053 and 4196 nM, respectively. KOR agonist 1 exhibits antinociceptive effect in ICR mouse model (ED50 in hot plate test is 0.3 mg/kg, in abdominal constriction test is 0.2 mg/kg)[1].

Applications: Neuroscience-Neuromodulation

Formula: C37H42N2O3

References: [1]Li Z, et al., Discovery of an Ortho-Substituted N-Cyclopropylmethyl-7α-phenyl-6,14-endoethano-tetrahydronorthebaine Derivative as a Selective and Potent Kappa Opioid Receptor Agonist with Subsided Sedative Effect. J Med Chem. 2024 May 9;67(9):7112-7129.

Molecular Weight: 562.74

Research Area: Neurological Disease

Target: Opioid Receptor

• SKU: MEXHY-161539-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-161539-0
• Package Unit: Get quote
• Quantity Unit: STK