Product Description: KSI-6666 is an orally active, competitive antagonist for sphingosine 1-phosphate receptor 1 (S1PR1), with an IC50 of 6.4 nM. KSI-6666 exhibits anti-inflammatory efficacy in autoimmune encephalomyelitis model and T cell transfer colitis model[1].
Applications: COVID-19-immunoregulation
Formula: C23H26ClF3N2O2
References: [1]Maruyama Y, et al. Pseudoirreversible inhibition elicits persistent efficacy of a sphigosine-1-phosphate receptor-1 antagonist[J]. bioRxiv, 2023: 2023.05. 08.539826.
CAS Number: 1807873-14-8
Molecular Weight: 454.91
Research Area: Inflammation/Immunology
Target: LPL Receptor