M4 mAChR Modulator-1

Product Description: M4 mAChR Modulator-1 (compound 23i) is a M4 mAChR positive allosteric modulator (PAM). M4 mAChR Modulator-1 exhibits significantly greater cooperativity with ACh in β-arrestin recruitment over G protein activation. M4 mAChR Modulator-1 displays weak PAM effect in G protein-mediated responses, but strong PAM effect in β-arrestin recruitment[1].

Formula: C22H23N5O

References: [1]Liu B, et al. Discovery of 2-Methyl-5-(1H-pyrazol-4-yl)pyridines and Related Heterocycles as Promising M4 mAChR Positive Allosteric Modulators for the Treatment of Neurocognitive Disorders. J Med Chem. 2024 Jul 18.

Molecular Weight: 373.45

Research Area: Neurological Disease

Target: mAChR

• SKU: MEXHY-159177-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-159177-0
• Package Unit: Get quote
• Quantity Unit: STK