Product Description: MAPK-IN-2 (compound 3h) is a potent MAPK inhibitor with antineoplastic activity. MAPK-IN-2 inhibits cancer cell proliferation among serval cancer cell lines, and suppresses MAPK pathway with potant efficacy (EGFRWT IC50=281 nM, c-MET IC50=205 nM, B-RAFWT IC50=112 nM, and CDK4/6 IC50=95 and 184 nM, respectively). MAPK-IN-2 even shows a remarkable potency against mutated EGFR and B-RAF (EGFRT790M IC50=69 nM and B-RAFV600E IC50=83 nM)[1].
Applications: Cancer-Kinase/protease
Formula: C20H11Cl2N3O
References: [1]Saleh MM, et al. The mystery of titan hunter: Rationalized striking of the MAPK pathway via Newly synthesized 6-Indolylpyridone-3-Carbonitrile derivatives. Eur J Med Chem. 2023 Nov 5;259:115675.
Molecular Weight: 380.23
Compound Purity: 98.54
Research Area: cancer
Solubility: 10 mM in DMSO
Target: CDK;c-Met/HGFR;EGFR;p38 MAPK;Raf
English
Deutsch
