MCUF-651, CAS 2747162-85-0

Product Description: MCUF-651 is an orally active guanylyl cyclase A receptor (GC-A) positive allosteric modulator (PAM) (KD: 397 nM ). MCUF-651 binds to GC-A and selectively enhances the binding of atrial natriuretic peptide (ANP) to GC-A. MCUF-651 enhances ANP-mediated cGMP generation in human cardiac, renal, and fat cells. MCUF-651 inhibits cardiomyocyte hypertrophy[1].

Applications: Neuroscience-Neuromodulation

Formula: C17H22F2N4OS

References: [1]Sangaralingham SJ, et al. Discovery of small molecule guanylyl cyclase A receptor positive allosteric modulators. Proc Natl Acad Sci U S A. 2021 Dec 28;118(52):e2109386118.

CAS Number: 2747162-85-0

Molecular Weight: 368.44

Compound Purity: 99.85

Research Area: Cardiovascular Disease

Solubility: DMSO : 50 mg/mL (ultrasonic)

Target: Guanylate Cyclase

• SKU: MEXHY-149453-100
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-149453-100
• Package Unit: 100 mg
• Quantity Unit: STK