Product Description: Mirtazapine (Org3770) is a potent and orally active noradrenergic and specific serotonergic antidepressant (NaSSA) agent. Mirtazapine is also a 5-HT2, 5-HT3, histamine H1 receptor and α2-adrenoceptor antagonist with pKi values of 8.05, 8.1, 9.3 and 6.95, respectively[1][2].
Applications: Neuroscience-Neuromodulation
Formula: C17H19N3
References: [1]S A Anttila, et al. A review of the pharmacological and clinical profile of mirtazapine. CNS Drug Rev. Fall 2001;7(3):249-64./[2]T H de Boer, et al. Neurochemical and autonomic pharmacological profiles of the 6-aza-analogue of mianserin, Org 3770 and its enantiomers. Neuropharmacology. 1988 Apr;27(4):399-408./[3]Wagdi Almishri, et al. The Antidepressant Mirtazapine Inhibits Hepatic Innate Immune Networks to Attenuate Immune-Mediated Liver Injury in Mice. Front Immunol. 2019 Apr 12;10:803.
CAS Number: 85650-52-8
Molecular Weight: 265.35
Compound Purity: 99.94
Research Area: Inflammation/Immunology; Neurological Disease; Cancer
Solubility: DMSO : 50 mg/mL (ultrasonic)/H2O : < 0.1 mg/mL
Target: 5-HT Receptor;Adrenergic Receptor;Histamine Receptor
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