Product Description: MK-571 (L-660711) is an orally active, potent and selective competitive leukotriene D4 (LTD4) receptor antagonist, with Ki values of 0.22 and 2.1 nM in guinea pig and human lung membranes, respectively. MK-571 is also a MRP4 and ABCC1 (MRP1) inhibitor. MK-571 inhibits constitutive and antigen-stimulated S1P (sphingosine-1-phosphate) release[1][2][3].
Applications: COVID-19-immunoregulation
Formula: C26H27ClN2O3S2
Citations: Biomed Pharmacother. 2020 Sep;129:110506./J Pharmaceut Biomed. 2020 Sep 10;189:113441./Nat Commun. 2023 Sep 19;14(1):5709./Viruses. 2019 Apr 24;11(4):378./Arch Toxicol. 2020 Nov;94(11):3799-3817./Biomed Pharmacother. 2018 Oct;106:1563-1569./Brain Res Bull. 2022 Aug 15;S0361-9230(22)00199-X./Cancer Res Commun. 2024 Apr 9;4(4):1024-1040./Cell. 2023 Dec 7;186(25):5500-5516.e21./CNS Neurosci Ther. 2022 Oct 17./Commun Biol. 2024 May 23;7(1):621./Eberhard Karls Universität Tübingen. 2022 Feb./Eur J Drug Metab Pharmacokinet. 2022 Feb 3./Eur J Drug Metab Pharmacokinet. 2024 Jul 4./Eur J Pharm Sci. 2023 May 1./Free Radic Biol Med. 2024 Jun 19:S0891-5849(24)00531-8./Int J Nanomedicine. 2019 Nov 27;14:9217-9234./J Appl Toxicol. 2024 Jul 18./Pharmaceutics. 2024 May 29./Pharmacol Res Perspect. 2022 Feb;10(1):e00928./Regul Toxicol Phar. 2019 Nov;108:104449. /Toxicol Lett. 2020 Jul 1;327:9-18./Xenobiotica. 2020 Mar;50(3):354-362.
References: [1]Jones TR, et al. Pharmacology of L-660,711 (MK-571): a novel potent and selective leukotriene D<sub>4</sub> receptor antagonist. Can J Physiol Pharmacol. 1989 Jan;67(1):17-28./[2]Hara Y, et al. Inhibition of MRP4 prevents and reverses pulmonary hypertension in mice. J Clin Invest. 2011 Jul;121(7):2888-97./[3]Mitra P, et al. Role of ABCC1 in export of sphingosine-1-phosphate from mast cells. Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16394-9.
CAS Number: 115104-28-4
Molecular Weight: 515.09
Compound Purity: 98.56
Research Area: Inflammation/Immunology
Solubility: DMSO : 175 mg/mL (ultrasonic)
Target: Leukotriene Receptor;LPL Receptor
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