Product Description: [Nle20] H4 peptide (16−23) is a peptide with strong inhibitory activity against histone methyltransferase SETD8 (Kd=0.14 μM), which inhibits SETD8's methylation of histone H4 by competing with SETD8's substrate binding site. [Nle20] H4 peptide (16−23) can be used as a lead compound for anticancer therapy[1].
Formula: C47H88N20O9
References: [1]Judge R A, et al. Turning a substrate peptide into a potent inhibitor for the histone methyltransferase SETD8[J]. ACS Medicinal Chemistry Letters, 2016, 7(12): 1102-1106.
CAS Number: 2042178-19-6
Molecular Weight: 1077.33
Research Area: Cancer
Target: Histone Methyltransferase