NSC-87877 (disodium), CAS 56932-43-5

NSC-87877 (disodium), CAS 56932-43-5
SKU
MEXHY-18756A-50
Packaging Unit
50 mg
Manufacturer
MedChemExpress

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Product Description: NSC-87877 disodium is a potent inhibitor of Shp2 and Shp1 protein tyrosine phosphatases (SH-PTP2 and SH-PTP1), with IC50 values of 0.318 μM, 0.355 μM shp2 and shp1, respectively[1]. NSC-87877 also inhibits dual-specificity phosphatase 26 (DUSP26)[2].

Applications: Cancer-Kinase/protease

Formula: C19H11N3Na2O7S2

References: [1]Chen L, et al. Discovery of a novel shp2 protein tyrosine phosphatase inhibitor. Mol Pharmacol. 2006 Aug;70(2):562-70./[2]Song M, et al. NSC-87877, inhibitor of SHP-1/2 PTPs, inhibits dual-specificity phosphatase 26 (DUSP26). Biochem Biophys Res Commun. 2009 Apr 17;381(4):491-5./[3]Y Shi, et al. NSC-87877 inhibits DUSP26 function in neuroblastoma resulting in p53-mediated apoptosis. Cell Death Dis. 2015 Aug 6;6(8):e1841.

CAS Number: 56932-43-5

Molecular Weight: 503.42

Compound Purity: 98.0

Research Area: Cancer

Solubility: DMSO : 125 mg/mL (ultrasonic)/H2O : 50 mg/mL (ultrasonic)

Target: Apoptosis;Phosphatase;SHP2
More Information
SKU MEXHY-18756A-50
Manufacturer MedChemExpress
Manufacturer SKU HY-18756A-50
Package Unit 50 mg
Quantity Unit STK
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