Product Description: NVP-AEW541 (AEW541 ) is an orally active inhibitor of the insulin-like growth factor 1 receptor (IGF-1R) with an IC50 value of 0.15 μM. NVP-AEW541 also inhibits InsR, IC50 with a value of 0.14 μM. NVP-AEW541 has antitumor activity[1].
Applications: Cancer-Kinase/protease
Formula: C27H29N5O
References: [1]García-Echeverría C, et al. In vivo antitumor activity of NVP-AEW541-A novel, potent, and selective inhibitor of the IGF-IR kinase. Cancer Cell. 2004 Mar;5(3):231-9./[2]Tanno B, et al. Down-regulation of IGF-1 receptor activity by NVP-AEW541 has an antitumor effect on neuroblastoma cells in vitro and in vivo. Clin Cancer Res. 2006, 12(22), 6772-6780.
CAS Number: 475489-16-8
Molecular Weight: 439.55
Compound Purity: 99.92
Research Area: Cancer; Endocrinology
Solubility: DMSO : 50 mg/mL (ultrasonic)
Target: Autophagy;IGF-1R;Insulin Receptor
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