Product Description: NVP-BVU972 is an selective and potent Met inhibitor, with an IC50 of 14 nM. NVP-BVU972 also exhibits good anti-proliferative activity against Met with drug-resistant mutations and inhibits phosphorylation. NVP-BVU972 can be used in study of cancer[1].
Applications: Cancer-Kinase/protease
Formula: C20H16N6
References: [1]Tiedt, Ralph, et al. A Drug Resistance Screen Using a Selective MET Inhibitor Reveals a Spectrum of Mutations That Partially Overlap with Activating Mutations Found in Cancer Patients. Cancer Research (2011), 71(15), 5255-5264.
CAS Number: 1185763-69-2
Molecular Weight: 340.38
Compound Purity: 98.38
Research Area: Cancer
Solubility: DMSO : 100 mg/mL (ultrasonic)
Target: c-Met/HGFR