Product Description: Orexin A (human, rat, mouse) (Hypocretin-1 (human, rat, mouse)) TFA, a 33 amino acid excitatory neuropeptide, orchestrates diverse central and peripheral processes. Orexin A (human, rat, mouse) TFA binds and activates two types of G protein-coupled receptors, the orexin-1 receptor (OX1R) and the orexin-2 receptor (OX2R). Orexin A (human, rat, mouse) TFA has a role in the regulation of feeding behavior. Orexin A (human, rat, mouse) TFA is an effective anti-nociceptive and anti-hyperalgesic agent in mice and rats[1][2][3].
Applications: Neuroscience-Neuromodulation
Formula: C152H243N47O44S4.xC2HF3O2
References: [1]Sakurai T, et al. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell. 1998 Feb 20;92(4):573-85./[2]Bingham S, et al. Orexin-A, an hypothalamic peptide with analgesic properties. Pain. 2001 May;92(1-2):81-90./[3]Kaminski T, et al. Expression of orexin receptors in the pituitary. Vitam Horm. 2012;89:61-73.
Molecular Weight: 3561.10 (free base)
Compound Purity: 97.13
Research Area: Neurological Disease
Solubility: H2O : 100 mg/mL (ultrasonic)
Target: Orexin Receptor (OX Receptor)
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