PROTAC ALK degrader-2

Product Description: PROTAC ALK degrader-2 (B1-PEG) is an ALK degrader based on PROTACs, with the DC50 of 45 nM in H3122 EML4-ALK DC50 (GSH+). PROTAC ALK degrader-2, through PEGylation, is engineered to self-organize into micelles in water and releases its active form in response to the tumor-specific high GSH environment[1].

Formula: C55H70ClN11O12S3.(C2H4O)n

References: [1]Shirui Wang, et al. Novel Amphiphilic PROTAC with Enhanced Pharmacokinetic Properties for ALK Protein Degradation. J Med Chem. 2024 Jun 27;67(12):9842-9856.

Molecular Weight: 3100 (Approximately)

Research Area: Cancer

Target: Anaplastic lymphoma kinase (ALK);PROTACs

• SKU: MEXHY-161750-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-161750-0
• Package Unit: Get quote
• Quantity Unit: STK