Product Description: PROTAC EGFR degrader 10 (Compound B56) is a PROTAC degrader for epidermal growth factor receptor (EGFR), with DC50 Ki of 37 nM. PROTAC EGFR degrader 10 degrades EGFR, focal adhesion kinase (FAK), and RSK1, inhibits the proliferation of BaF3 wild type and EGFR mutants, with IC50 [1].
Applications: Cancer-Kinase/protease
Formula: C49H65ClN10O7S
References: [1]Han W, et al., Compound for targeted protein degradation, and use thereof. WO2024072178A1
CAS Number: 3034244-56-6
Molecular Weight: 973.62
Research Area: Cancer
Target: EGFR;FAK;PROTACs