Product Description: Q14 is a polypeptide derived from the USP30 (ubiquitin specific peptidase 30) transmembrane (TM) domain with the ability to inhibit the deubiquitination activity of USP30 (IC50=57.2 nM). Q14 reduces USP30 activity by inhibiting the interaction between the USP30 transmembrane domain and its catalytic domain. Q14 peptide contains the LC3 interaction region (LIR) motif, which enables it to bind to the LC3 and accelerate the formation of autophagosomes, thereby promoting mitophagy. Q14 can be used in the study of neurodegenerative diseases as well as mitochondrial quality control and cell metabolism[1].
Applications: Neuroscience-Neurodegeneration
Formula: C99H166N32O22
References: [1]Qin X, et al. Identification of an autoinhibitory, mitophagy-inducing peptide derived from the transmembrane domain of USP30[J]. Autophagy, 2022, 18(9): 2178-2197.
Molecular Weight: 2156.58
Research Area: Neurological Disease; Others
Target: Deubiquitinase;Mitophagy
English
Deutsch
