rac-Olodanrigan, CAS 152362-51-1

Product Description: rac-Olodanrigan (rac-EMA401; EMA400) is a racemic mixture of the S-enantiomer (EMA401; HY-13106) and R-enantiomer (EMA402). rac-Olodanrigan is a potent and selective AT2 receptor antagonist with IC50s of 75.2 nM and 2918 nM for AT2R and AT1R, respectively. rac-Olodanrigan evokes dose-dependent relief of mechanical allodynia in the ipsilateral hind paws of rats with a chronic constriction injury (CCI) of the sciatic nerve[1].

Formula: C32H29NO5

References: [1]Maree T Smith. Nonopioid analgesics discovery and the Valley of Death: EMA401 from concept to clinical trial. Pain. 2022 Nov 1;163(Suppl 1):S15-S28.

CAS Number: 152362-51-1

Molecular Weight: 507.58

Research Area: Neurological Disease

Target: Angiotensin Receptor

• SKU: MEXHY-19202-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-19202-0
• Package Unit: Get quote
• Quantity Unit: STK