SOS1/EGFR-IN-1, CAS 2956724-20-0

Product Description: SOS1/EGFR-IN-1 (compound SE-9) is a dual-target inhibitor for the prostate cancer. SOS1/EGFR-IN-1 inhibits effectively SOS1(IC50=42.13±1.55 nM) and EGFR(IC50=1.01±0.04 nM) by inhibiting their downstream effector molecules. SOS1/EGFR-IN-1 induces apoptosis and G1 phase cell cycle arrest, reducing angiogenesis and migration. SOS1/EGFR-IN-1 shows significant antitumor effects in prostate cancer cells PC-3 (IC50=0.45±0.03 μM)[1].

Applications: Cancer-Kinase/protease

Formula: C22H24FN3O3

References: [1]Zheng L, et al. Discovery of a Potent Dual Son of Sevenless 1 (SOS1) and Epidermal Growth Factor Receptor (EGFR) Inhibitor for the Treatment of Prostate Cancer[J]. Journal of Medicinal Chemistry, 2024.

CAS Number: 2956724-20-0

Molecular Weight: 397.44

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: EGFR;Ras

• SKU: MEXHY-158310-5
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-158310-5
• Package Unit: 5 mg
• Quantity Unit: STK