Product Description: Spadin TFA, a natural peptide derived from a propeptide released in blood, is a potent TREK-1 channel blocker with an IC50 value of 10 nM. Spadin TFA enhances dorsal raphe nucleus 5-HT neurotransmission in mice and induces hippocampal CREB activation and neurogenesis. Spadin TFA can be used for antidepressant research[1][2].
Applications: Neuroscience-Neuromodulation
Formula: C92H143F3N26O24
References: [1]Borsotto M, et, al. Targeting two-pore domain K(+) channels TREK-1 and TASK-3 for the treatment of depression: a new therapeutic concept. Br J Pharmacol. 2015 Feb;172(3):771-84. /[2]Mazella J, et, al. Spadin, a sortilin-derived peptide, targeting rodent TREK-1 channels: a new concept in the antidepressant drug design. PLoS Biol. 2010 Apr 13;8(4):e1000355.
Molecular Weight: 2126.36
Compound Purity: 99.73
Research Area: Neurological Disease
Solubility: H2O : 25 mg/mL (ultrasonic)
Target: 5-HT Receptor;Potassium Channel
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