Product Description: Stalk peptide is a GPR110 activator. Stalk peptide is released from GPCR Autoproteolysis INducing domain by autocatalytic process and then Stalk peptide is inserted into the ligand-binding pocket of the receptor to activate the receptor. Stalk peptide can promote nerve growth and synaptic formation. Stalk peptide can be used to study neurodevelopmental and neurodegenerative diseases[1].
Applications: Neuroscience-Neurodegeneration
Formula: C48H77N11O16S
References: [1]Zhu X, et al. Structural basis of adhesion GPCR GPR110 activation by stalk peptide and G-proteins coupling[J]. Nature Communications, 2022, 13(1): 5513.