Product Description: SUN-1334H free base is an orally active inhibitor for histamine H1 receptor, with an IC50 of 20.3 nM and Ki of 9.7 nM. SUN-1334H free base inhibits histamine-induced contractions of isolated guinea-pig ileum with an IC50 of 0.198 μM. SUN-1334H free base inhibits histamine-induced bronchoconstriction in guinea pigs, histamine-induced skin wheals in beagle dogs, and ovalbumin-induced rhinitis in guinea pigs[1].
Applications: COVID-19-immunoregulation
Formula: C23H26F2N2O3
References: [1]Mandhane SN, et al., Preclinical efficacy and safety pharmacology of SUN-1334H, a potent orally active antihistamine agent. Drugs R D. 2008;9(2):93-112.
CAS Number: 607737-00-8
Molecular Weight: 416.46
Research Area: Inflammation/Immunology; Cardiovascular Disease
Target: Adrenergic Receptor;Dopamine Receptor;Histamine Receptor;Sigma Receptor
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