Product Description: TAX2 peptide is a dodecapeptide based on molecular docking and simulation design, derived from the cell surface receptor CD47 sequence. TAX2 peptide acts as a selective antagonist of TSP-1 (thromboxin-1) interacting with CD47. TAX2 peptide can promote the binding of TSP-1 to CD36, which leads to the destruction of VEGFR2 (vascular endothelial growth factor receptor 2) activation, thereby blocking downstream NO (nitric oxide) signaling, demonstrating anti-angiogenic properties. TAX2 peptide can be used to study angiogenesis and tumor cell interactions in the tumor microenvironment[1].
Applications: Cancer-Kinase/protease
Formula: C51H86N14O19S2
References: [1]Jeanne A, et al. Identification of TAX2 peptide as a new unpredicted anti-cancer agent[J]. Oncotarget, 2015, 6(20): 17981.
Molecular Weight: 1263.44
Research Area: Cancer
Target: TGF-β Receptor
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