TRK-IN-29

Product Description: TRK-IN-29 (Compound B31) is a second-generation TRK inhibitor (IC50: 9 nM, 0.6 nM, 18 nM, 5 nM, 6 nM for TRKAG595R, TRKAF589L, TRKAG667C, TRKA and TRKC respectively). TRK-IN-29 inhibits the phosphorylation of TRKA. TRK-IN-29 has good antiproliferative activities against NTRK fusion positive cells. TRK-IN-29 has exellent plasma stability and moderate pharmacokinetic properties[1].

Applications: Cancer-Kinase/protease

Formula: C19H17F3N6O

References: [1]Qiaohua Qin, et al. Discovery of novel indazole derivatives as second-generation TRK inhibitors. European Journal of Medicinal Chemistry. Available online 1 July 2024, 116640, et al.

Molecular Weight: 402.37

Research Area: Cancer

Target: Trk Receptor

• SKU: MEXHY-161819-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-161819-0
• Package Unit: Get quote
• Quantity Unit: STK