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Applications: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Assay Conditions: The assay was conducted following USP20 Inhibitor Screening Assay Kit (#78840) with increasing amounts of USP21, His-Tag, FLAG-Tag, Recombinant.
Background: Ubiquitin specific peptidase 21 (USP21) belongs to a large group of ubiquitin-specific proteases capable of cleaving ubiquitin from other proteins. These enzymes are also referred to as deubiquitinating peptidases, deubiquitinases (DUBs), ubiquitin proteases, ubiquitin hydrolases or ubiquitin isopeptidases. They contribute to the ubiquitin signaling pathway by countering the signal induced by ubiquitin conjugating enzymes and ligases. DUBs are a new therapeutic target for neurodegenerative diseases, cancer, diabetes, and autoimmune pathologies.
Description: Recombinant full length human USP21 (Ubiquitin Specific Protease 21), amino acids 2-566(end). This construct contains an N-terminal His-tag (6xHis) and a C-terminal FLAG-tag. This protein was affinity purified.
Format: Aqueous buffer solution.
Formulation: 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol
Genbank: NM_012475
Host Cell Line: HEK293
Purity: ≥85%
Storage Stability: At least 6 months at -80°C.
Tags: N-terminal His-Tag, C-terminal FLAG-Tag
Uniprot: Q9UK80
Warnings: Avoid freeze/thaw cycles
Biosafety Level: Not applicable (BSL-1)
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