Product Description: Vatinoxan (MK-467) is an alpha 2-adrenergic receptor antagonist. The peripheral selectivity of Vatinoxan determines that it has limited penetration across the blood-brain barrier and therefore has low concentrations in the central nervous system. Vatinoxan antagonizes alpha 2-adrenergic receptor receptors by binding to them, thereby reducing or preventing cardiovascular effects caused by α2-adrenergic agonists. Vatinoxan can be used in studies of cardiovascular effects, sedation and analgesia[1].
Applications: Neuroscience-Neuromodulation
Formula: C20H26N4O4S
References: [1]Honkavaara J M, et al. Concentrations of medetomidine enantiomers and vatinoxan, an α2-adrenoceptor antagonist, in plasma and central nervous tissue after intravenous coadministration in dogs[J]. Veterinary anaesthesia and analgesia, 2020, 47(1): 47-52.
CAS Number: 114914-42-0
Molecular Weight: 418.51
Research Area: Neurological Disease; Cardiovascular Disease
Target: Adrenergic Receptor
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