VU0092273, CAS 393110-43-5

Product Description: VU0092273 is a potent mGlu5 positive allosteric modulator (PAM) that also binds to the MPEP site, with an EC50 of 0.27 μM[1][2].

Formula: C20H19NO2

References: [1]Douglas J Sheffler, et al. Development of a novel, CNS-penetrant, metabotropic glutamate receptor 3 (mGlu3) NAM probe (ML289) derived from a closely related mGlu5 PAM. Bioorg Med Chem Lett. 2012 Jun 15;22(12):3921-5./[2]Alice L Rodriguez, et al. Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity. Mol Pharmacol. 2010 Dec;78(6):1105-23.

CAS Number: 393110-43-5

Molecular Weight: 305.37

Research Area: Neurological Disease

Target: mGluR

• SKU: MEXHY-19623-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-19623-0
• Package Unit: Get quote
• Quantity Unit: STK