VU0448088, CAS 1417616-42-2

Product Description: VU0448088 (ML253) is a potent and cross the blood-brain barrier tricyclic muscarinic acetylcholine receptor subtype 4 (M4) positive allosteric modulator with EC50 values of 56, 176 nM for human and rat, respectively. VU0448088 has the potential for the research of psychotic[1][2].

Formula: C16H15ClN4OS

References: [1]Le U, et al. Discovery of a selective M₄ positive allosteric modulator based on the 3-amino-thieno[2,3-b]pyridine-2-carboxamide scaffold: development of ML253, a potent and brain penetrant compound that is active in a preclinical model of schizophrenia. Bioorg Med Chem Lett. 2013 Jan 1;23(1):346-50.

CAS Number: 1417616-42-2

Molecular Weight: 346.83

Research Area: Neurological Disease

Target: mAChR

• SKU: MEXHY-162663-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-162663-0
• Package Unit: Get quote
• Quantity Unit: STK