Product Description: Xaliproden hydrochloride (SR57746A) is a potent, selective and orally active agonist of 5-HT1A receptor, shows a high affinity for 5-HT1A specific binding sites in the rat hippocampus (IC50=3 nM). Xaliproden hydrochloride is also a selective antagonist of dopamine D2 receptor, has moderate affinity (IC50=0.1-1 μM). Xaliproden hydrochloride exhibits anti-depression and anti-anxiety effects, and it may possess therapeutic potential for the research of neurodegenerative diseases[1][2][3].
Applications: Neuroscience-Neurodegeneration
Formula: C24H23ClF3N
References: [1]Cervo L, et, al. Potential antidepressant properties of SR 57746A, a novel compound with selectivity and high affinity for 5-HT1A receptors. Eur J Pharmacol. 1994 Feb 21; 253(1-2): 139-47./[2]Simiand J, et, al. Neuropsychopharmacological profile in rodents of SR 57746A, a new, potent 5-HT1A receptor agonist. Fundam Clin Pharmacol. 1993;7(8):413-27./[3]Fournier J, et, al. Protective effects of SR 57746A in central and peripheral models of neurodegenerative disorders in rodents and primates. Neuroscience. 1993 Aug; 55(3): 629-41.
CAS Number: 90494-79-4
Molecular Weight: 417.89
Compound Purity: 98.57
Research Area: Neurological Disease
Solubility: DMSO : 33.33 mg/mL (ultrasonic)
Target: 5-HT Receptor;Dopamine Receptor
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