Product Description: xStAx-VHLL is a PROTAC β-catenin degrader that manifests strong inhibition of Wnt signaling and sustains degradation of β-catenin in cancer cells and the intestinal organoids derived from wild-type and APC–/– mice. xStAx-VHLL can be used as a promising anticancer agent[1].
Applications: Cancer-programmed cell death
Formula: C154H244N48O29
References: [1]Liao H, et al. A PROTAC peptide induces durable β-catenin degradation and suppresses Wnt-dependent intestinal cancer. Cell Discov. 2020 Jun 9;6:35.