Formulation: A crystalline solid
Formal Name: 2,3,4,5-tetrahydro-7-methoxy-4-methyl-1,4-benzothiazepine
Purity: ≥98%
Formula Markup: C11H15NOS
Formula Weight: 209,3
Shelf life (days): 1460
CAS Number: 927871-76-9
Notes: S107 is a stabilizer of the protein-protein interaction between ryanodine receptor 1 (RyR1) and FK-506 binding protein 1A (FKBP12).{17068,17069} It stabilizes sarcoplasmic reticulum RyR1 channels by decreasing the dissociation of FKBP12 in isolated mouse muscle fibers.{17069} S107 (50 and 100 µM) also reduces neurite growth and length in isolated spinal cords from neonatal rats.{51415} Ex vivo, S107 reduces exercise-induced calcium leakage in mouse muscle fibers.{17068} S107 decreases muscle fatigue and increases treadmill running time in mice. It increases grip strength and reduces exercise-induced muscle damage in a dystrophin DMD-/- knockout mouse model of Duchenne muscular dystrophy.{17069}
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