Sinefungin (trifluoroacetate salt)

Formulation: A solid

Formal Name: 2S,5S-diamino-6-((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)hexanoic acid, trifluoroacetate salt

Purity: ≥95%

Formula Markup: C15H23N7O5 • XCF3COOH

Formula Weight: 381,4

Shelf life (days): 1460

Notes: Sinefungin is a purine nucleoside and derivative of S-adenosylhomocysteine (Item No. 13603) that has been found in Streptomyces and has diverse biological activities.{18391,18646} It inhibits G9a methyltransferase and SET domain-containing protein 7 (SET7) with IC50 values of 10.4 and 2.38 µM, respectively, using histone H3 (1-21) peptide as a substrate and 150 and 9.1 µM, respectively, using full-length histone H3 as a substrate.{24147} It also inhibits protein arginine methyltransferase 5 (PRMT5) with IC50 values of 0.31 and 0.69 µM using histone H4 (1-21) peptide and full-length histone H4, respectively, as substrates. Sinefungin (10 mg/kg) reduces renal levels of the mesenchymal marker α-smooth muscle actin (α-SMA), fibrosis markers ferroptosis suppressor protein 1 (Fsp1), collagen 1, collagen 3, and fibronectin, and monomethylation of histone H3 lysine 4 (H3K4me1) in a mouse model of unilateral ureteral obstruction.{68756}

• SKU: CAY41004-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 41004-5
• Package Unit: 5 mg
• Quantity Unit: STK