Formulation: A solid
Formal Name: 4S-(3,4-dichlorophenyl)-1S,2,3,4-tetrahydro-N-methyl-1-naphthalenamine, monohydrochloride
Purity: ≥95%
Formula Markup: C16H15Cl2N • HCl
Formula Weight: 328,7
Shelf life (days): 1460
CAS Number: 675126-10-0
Notes: (1S,4S)-N-desmethyl Sertraline is a metabolite of the selective serotonin reuptake inhibitor (SSRI) sertraline (Item No. 14839).{68667} (1S,4S)-N-desmethyl Sertraline inhibits serotonin (5-HT) and dopamine (DA) uptake in isolated rat corpus striatum (IC50s = 0.45 and 3.8 µM, respectively) and norepinephrine (NE) uptake in isolated rat hypothalamus (IC50 = 4.6 µM).{62332} Unlike sertraline, (1S,4S)-N-desmethyl sertraline (1, 3.2, and 10 mg/kg) does not increase extracellular levels of 5-HT or decrease extracellular levels of the serotonin metabolite 5-hydroxy indole-3-acetic acid (5-HIAA) in the rat striatum.{68668} It also does not increase cell firing in the rat dorsal raphe when administered intravenously at a dose of 1,000 µg/kg.
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