Formulation: A solid
Purity: ≥95%
Formula Markup: C7H6O4
CAS Number: 303-38-8
Notes: 2,3-Dihydroxybenzoic acid is a phenol that has been found in F. inermis, has antifungal and antioxidant activities, and is an active metabolite of the NSAID and COX inhibitor aspirin (Item No. 70260) and its metabolite salicylic acid.{51704,51705,51702,51703} It is formed from salicylic acid by the cytochrome P450 (CYP) isoform CYP2E1 in human liver microsomes.{51702} It is active against the opportunistic fungi A. fumigatus, A. flavus, A. niger, and Chrysosporium.{51704} 2,3-Dihydroxybenzoic acid (1 µM) reduces apoptosis, increases autophagy, glutathione (GSH) levels, and superoxide dismutase (SOD) activity, and reduces glutathione peroxidase (GPX) activity in primary rat embryonic H9c2 cardiomyocytes under high-glucose and high-palmitic acid conditions as an in vitro model of diabetic cardiomyopathy.{51705}
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