Formulation: A solid
Formal Name: 2'-deoxy-5-fluoro-cytidine
Purity: ≥98%
Formula Markup: C9H12FN3O4
Formula Weight: 245,2
Shelf life (days): 1460
CAS Number: 10356-76-0
Notes: 2'-Deoxy-5-fluorocytidine is an antimetabolite, an inhibitor of DNA methylation and deoxycytidine kinase, and a prodrug form of the FdUMP prodrug 5-fluorouracil (Item No. 14416).{69530,69531,69532,69533} Incorporation of 2'-deoxy-5-fluorocytidine into a synthetic DNA polymer inhibits methylation of DNA in a cell-free assay, and 2'-deoxy-5-fluorocytidine-containing oligonucleotides form a covalent complex with DNA methyltransferase 3a (Dnmt3a).{69530,69531} 2'-Deoxy-5-fluorocytidine inhibits deoxycytidine kinase (dCK; IC50 = 120 nM).{69532} It reduces the cytopathic effects of the influenza H5N1 strain Vietnam/1203/2004 in MDCK cells (IC50 = 0.19 µM).{69534} 2'-Deoxy-5-fluorocytidine (12 mg/kg) in combination with the cytidine deaminase inhibitor tetrahydrouridine (Item No. 16402) inhibits tumor growth in an ascitic mammary adenocarcinoma 755 murine model.{69533} It induces embryonic lethality and skeletal malformations in a dose-dependent manner when administered to pregnant mice.{69535}
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