Formulation: A solid
Formal Name: 3-ethyl-2-[3-(3-ethyl-2(3H)-benzoxazolylidene)-1-propen-1-yl]-benzoxazolium, monoiodide
Purity: ≥95%
Formula Markup: C21H21N2O2 • I
Formula Weight: 460,3
Shelf life (days): 1460
CAS Number: 905-96-4
Notes: 3,3′-Diethyloxacarbocyanine (DiOC2(3)) is a cationic fluorescent dye that has been used to monitor mammalian and bacterial membrane potential.{64569,69679,69680,69681} Upon cell hyperpolarization, it enters cells, and exhibits a decrease in fluorescence intensity and shift in emission from 530 nm to 670 nm upon excitation at 488 nm.{69681} DiOC2(3) selectively inhibits bovine heart mitochondrial complex I, also known as NADH dehydrogenase (IC50 = 9 µM), over bovine heart mitochondrial complex IV, also known as cytochrome c oxidase, and P. denitrificans mitochondrial complex I but activates bovine heart mitochondrial complex II, also known as succinate dehydrogenase, at 10 µM.{69682}
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