Formulation: A solid
Formal Name: 2-(3,4-dimethoxyphenyl)-3,5,6,7,8-pentamethoxy-H-1-benzopyran-4-one
Purity: ≥98%
Formula Markup: C22H24O9
Formula Weight: 432,4
Shelf life (days): 1460
CAS Number: 1178-24-1
Notes: 3,5,6,7,8,3',4'-Heptamethoxyflavone (HMF) is a polymethoxyflavone that has been found in C. reticulata and has diverse biological activities.{25346,61964,52726,61965} It inhibits the efflux of Hoechst 33342 (Item No. 15547) by breast cancer resistance protein (BCRP) and rhodamine 123 (Item No. 16672) by P-glycoprotein (P-gp), also known as multidrug resistance protein 1 (MDR1), in MDCK cells expressing the human transporters (IC50s = 1.4 and 31 µM, respectively).{25346} HMF (50, 100, and 200 µg/ml) prevents UVB-induced decreases in type I procollagen in primary human dermal fibroblast neonatal (HDFn) cells.{61964} It inhibits the proliferation of B16 melanoma 4A5, CCRF-HSB-2 leukemia, and TGBC11TKB gastric cancer cells (IC50s = 38, 29, and 9 µM, respectively).{52726} HMF (50 mg/kg) prevents corticosterone-induced increases in immobility time in the forced swim test in mice.{61965}
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