Formulation: A solid
Formal Name: 2-(3,4-dimethoxyphenyl)-5,7-dimethoxy-4H-1-benzopyran-4-one
Purity: ≥98%
Formula Markup: C19H18O6
Formula Weight: 342,3
Shelf life (days): 1460
CAS Number: 855-97-0
Notes: 5,7,3',4'-Tetramethoxyflavone is a flavone that has been found in M. paniculata and has diverse biological activities.{66043,72147,65988,65989,65990,65991} It selectively inhibits multidrug resistance-associated protein 1 (MRP1) over MRP2 (IC50s = 7.9 and >50 µM, respectively).{66043} 5,7,3',4'-Tetramethoxyflavone (0.03-30 µM) inhibits LPS-induced nitric oxide (NO) release in primary mouse peritoneal macrophages.{72147} It is active against P. falciparum (IC50 = 4.06 µg/ml).{65988} 5,7,3',4'-Tetramethoxyflavone (20 µM) is cytotoxic to B16/F10 melanoma cells.{65989} It inhibits IL-33-induced production of chemokine (C-C motif) ligand 2 (CCL2) and CCL5 in primary human mast cells when used at concentrations of 50 and 100 µM.{65990} In vivo, 5,7,3',4'-tetramethoxyflavone (100 mg/kg) decreases the synovial fluid levels of prostaglandin E2 (PGE2; Item No. 14010), IL-1β, and TNF-α in a rat model of surgically induced osteoarthritis.{65991}
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