Formulation: A solid
Formal Name: (R)-N,N-dimethyl-3-((5-(1-(1-phenylethyl)-1H-[1,2,3]triazolo[4,5-c]quinolin-8-yl)pyridin-2-yl)oxy)propan-1-amine
Purity: ≥95%
Formula Markup: C27H28N6O
Formula Weight: 452,6
Shelf life (days): 1095
Notes: A011 is an inhibitor of ataxia-telangiectasia mutated (ATM) kinase (IC50 = 1 nM).{68469} It is selective for ATM over a panel of 408 additional kinases at 10 µM. A011 inhibits the growth of SW620 and HCT116 colorectal cancer cells (IC50s = 0.14 and 0.91 µM, respectively) and enhances cell death induced by DNA topoisomerase I inhibitor irinotecan (Item No. 14180) in the same cells when used at concentrations of 10, 30, and 100 nM. It also increases irradiation-induced cell death in SW620 cells. In vivo, A011 (5 mg/kg) increases irinotecan-induced reductions in tumor growth in an SW620 mouse xenograft model.
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