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Applications: Useful for as a potent, cell permeable proteasome inhibitor for drug discovery research.
CAS Number: 57576-44-0
Description: Aclacinomycin A is a specific inhibitor of the 20S proteasome chymotrypsin-like activity and calpain activity. Aclarubicin acts by forming a stable complex with DNA. It was originally identified as an antitumor agent. Cell permeable.
Format: Orange powder
Purity: ≥95% by TLC.
Solubility: Soluble in DMSO (30 mg/ml)
Storage Stability: Store at +4°C. Stable as supplied for up to 2 years when stored dessicated at +4°C. Store solutions at -20°C for up to 1 month.
Warnings: Protect from light. Protect from moisture. Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: 1. Figueiroda-Pereira, M.E., et al.; J. Biol. Chem. 1996, 271: 16455