Afatinib (maleate), CAS 850140-73-7

Formulation: A crystalline solid

Formal Name: N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2E-butenamide, 2Z-butenedioate (1:2)

Purity: ≥95%

Formula Markup: C24H25ClFN5O3 • 2C4H4O4

Formula Weight: 718,1

Shelf life (days): 1460

CAS Number: 850140-73-7

Notes: Afatinib is an irreversible inhibitor of epidermal growth factor receptor (EGFR) and ErbB2 (IC50s = 0.5 and 14 nM, respectively).{33871} It increases the cytotoxicity of adriamycin in a concentration-dependent manner in multidrug-resistant A549T lung cancer cells overexpressing P-glycoprotein.{42401} Afatinib (20 mg/kg) reduces tumor growth in ErbB2-amplified NCI-N87 and NUGC4 gastric cancer mouse xenograft models.{42402} Formulations containing afatinib have been used in the treatment of non-small cell lung cancer.

• SKU: CAY21567-100
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 21567-100
• Package Unit: 100 mg
• Quantity Unit: STK