AG-270, CAS 2201056-66-6

Formulation: A solid

Formal Name: 3-(1-cyclohexen-1-yl)-6-(4-methoxyphenyl)-2-phenyl-5-(2-pyridinylamino)-pyrazolo[1,5-a]pyrimidin-7(4H)-one

Purity: ≥98%

Formula Markup: C30H27N5O2

Formula Weight: 489,6

Shelf life (days): 1460

CAS Number: 2201056-66-6

Notes: AG-270 is an inhibitor of methionine adenosyltransferase 2A (MAT2A; IC50 = 0.014 µM).{67169} It reduces levels of S-(5'-adenosyl)-L-methonine (SAM; Item Nos. 16376 / 17595) in, and inhibits the proliferation of, HCT116 cells with a homozygous deletion of MTAP, the gene encoding methylthioadenosine phosphorylase (IC50s = 0.2 and 0.257 µM, respectively). AG-270 (200 mg/kg) reduces intratumor SAM levels and tumor growth in KP4 and HCT116 MTAP-null, but not HCT116 MTAP-wild-type, mouse xenograft models.

• SKU: CAY36246-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 36246-5
• Green Labware: No
• Package Unit: 5 mg
• Quantity Unit: STK
• Application: Reinstoffe