Formulation: A solid
Formal Name: 1-methyl-5-(2′-methyl[1,1′-biphenyl]-4-yl)-1H-benzotriazole-7-carboxylic acid
Purity: ≥98%
Formula Markup: C21H17N3O2
Formula Weight: 343,4
Shelf life (days): 1460
CAS Number: 1623416-31-8
Notes: AG-636 is a dihydroorotate dehydrogenase (DHODH) inhibitor (IC50 = 17 nM).{68068} It increases levels of ureidosuccinic acid (Item No. 34126) and DHO, pyrimidine biosynthesis metabolites upstream of DHODH, in a panel of six cell lines when used at a concentration of 1 µM. AG-636 (100 mg/kg) induces complete tumor stasis in an OCI-Ly19 diffuse large B cell lymphoma (DLBCL) mouse xenograft model and complete tumor regression in a Z-138 ibrutinib-resistant mantle cell lymphoma mouse xenograft model. It also increases DHO levels and reduces pyrimidine levels in Z-138 and JeKo-1 lymphoma mouse xenograft models.
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