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Biological Activity: AGK2 inhibits SIRT2 with an IC50 value of 3.5 µM.
CAS Number: 304896-28-4
Description: AGK2 is a selective, cell-permeable inhibitor of SIRT2. It has minimal effects SIRT1 and SIRT3 at 10-fold higher levels compared to SIRT2. Useful for studing SIRT2 in neurodegeneration and aging, as well as cell cycle progression and tumorigenesis.
Format: A crystalline solid
Purity: ≥98% by HPLC
Solubility: Soluble in DMSO and DMF purged with an inert gas. Solubility is approximately 1mg/ml in DMSO and approximately 3 mg/ml in DMF.
Storage Stability: Store at or below -20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Biosafety Level: Not applicable (BSL-1)
References: Outeiro, T.F., et al., Science. 2007;317:516-519.
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