Formulation: A solution in ethanol
Formal Name: (αR,γS)-γ-[(3-carboxy-1-oxopropyl)amino]-α-methyl-[1,1′-biphenyl]-4-pentanoic acid, α-ethyl ester
Purity: ≥98%
Formula Markup: C24H29NO5
Formula Weight: 411,5
Shelf life (days): 365
CAS Number: 149709-62-6
Notes: AHU377 is an ethyl ester prodrug from of the neprilysin inhibitor LBQ657 (Item No. 19829).{42277} It increases plasma levels of atrial natriuretic factor (ANF) in conscious rats and anesthetized dogs when administered at doses of 10 and 30 mg/kg, respectively. AHU377 (30 mg/kg) increases ANF-induced urinary sodium excretion in anesthetized rats. Formulations containing AHU377 in combination with valsartan have been used in the treatment of mild to moderate hypertension and chronic heart failure.