ALK-IN-1, CAS 1197958-12-5

Formulation: A crystalline solid

Formal Name: 5-​chloro-​N2-​[4-​[4-​(dimethylamino)​-​1-​piperidinyl]​-​2-​methoxyphenyl]​-​N4-​[2-​(dimethylphosphinyl)​phenyl]​-2,​4-​pyrimidinediamine

Purity: ≥98%

Formula Markup: C26H34ClN6O2P

Formula Weight: 529

Shelf life (days): 1460

CAS Number: 1197958-12-5

Notes: ALK-IN-1 is an analog of AP26113, a phosphine oxide-containing ALK inhibitor. ALK-IN-1 potently inhibits ALK (IC50 = 0.07 nM) over IGF-1R and InsR (IC50s = 3.2 and 100 nM, respectively).{31299} It drives cell death in (ALK+) Karpas-299 lymphoma cells with an IC50 value of 41.5 nM, while killing (ALK-) U937 cells with an IC50 value of 1,718 nM.{31299}

• SKU: CAY18775-25
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 18775-25
• Package Unit: 25 mg
• Quantity Unit: STK