AM114, CAS 856849-35-9

Formulation: A solid

Formal Name: B,B′-[(1-methyl-4-oxo-3,5-piperidinediylidene)bis(methylidyne-4,1-phenylene)]bis-boronic acid

Purity: ≥95%

Formula Markup: C20H21B2NO5

Formula Weight: 377

Shelf life (days): 1460

CAS Number: 856849-35-9

Notes: AM114 is an inhibitor of the 20S proteasome (IC50 = ~1 µM).{66938} It induces the accumulation of ubiquitinated proteins in HCT116 colon cancer cells when used at a concentration of 1 µM. AM114 sensitizes HCT116 p53+/+ and HCT116 p53-/- cells to ionizing radiation-induced cytotoxicity in an additive and synergistic manner, respectively. It decreases the viability of macrophages isolated from patients with rheumatoid arthritis (IC50 = 0.88 µM).{66939}

• SKU: CAY42040-25
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 42040-25
• Package Unit: 25 mg
• Quantity Unit: STK