AMG PERK 44 (hydrochloride)

Formulation: A solid

Formal Name: 4-(2-amino-4-methyl-3-(2-methylquinolin-6-yl)benzoyl)-1-methyl-2,5-diphenyl-1,2-dihydro-3H-pyrazol-3-one, hydrochloride

Purity: ≥98%

Formula Markup: C34H28N4O2• XHCl

Formula Weight: 561,1

Shelf life (days): 1460

Notes: AMG PERK 44 is a protein kinase R-like ER kinase (PERK) inhibitor (IC50 = 6 nM).{68767} It is selective for PERK over general control nonderepressible 2 kinase (GCN2) and B-RAF (IC50s = 7,300 and >1,000 nM, respectively). It inhibits PERK autophosphorylation in a cell-free assay (IC50 = 84 nM) and rescues protein synthesis in U2OS cells (EC50 = 400 nM). AMG PERK 44 (1, 3, 10, and 30 mg/kg) reduces intratumoral PERK autophosphorylation in a doxycycline-inducible PERK Matrigel™ plug assay.

• SKU: CAY19126-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 19126-5
• Package Unit: 5 mg
• Quantity Unit: STK