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Background: Aminophylline is a bronchodilator that is used together with other medicines to treat the acute symptoms of asthma, bronchitis, emphysema, and other lung diseases. Aminophylline is also a competitive adenosine receptor antagonist and it is thought to have potential therapeutic value for cardiac ischemia.
CAS Number: 317-34-0
Description: Aminophylline is a non-selective phosphodiesterase (PDE) inhibitor with an IC50 of 0.12 mM. Inhibition of PDE prevents the breakdown of secondary messenger molecules cAMP and cGMP, which play a vital role in signal transduction.
Format: white to off-white powder
Solubility: Soluble in water (3.7 mg/ml). Solutions should be freshly prepared. Not soluble in alcohols.
Storage Stability: Store at or below -20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Target: PDE
Biosafety Level: Not applicable (BSL-1)
References: 1. Crisanti, et al., Am. J. Physiol. 277, R829-R835, (1999).
2. Chanda, et al., Pol. J. Pharmacol. 50, 80-82, (1998).
3. Thakker, et al. Analytical Profiles of Drug Substances 2nd ed., (1982) 2, 1-44.
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