Formulation: A solid
Formal Name: N-[2-[[2-[(2S)-2-cyano-1-pyrrolidinyl]-2-oxoethyl]amino]-2-methylpropyl]-2-methyl-pyrazolo[1,5-a]pyrimidine-6-carboxamide
Purity: ≥95%
Formula Markup: C19H25N7O2
Formula Weight: 383,5
Shelf life (days): 1460
CAS Number: 739366-20-2
Notes: Anagliptin is an inhibitor of dipeptidyl peptidase 4 (DPP-4; IC50 = 3.8 nM).{64684} It is selective for DPP-4 over DPP-8 and DPP-9 (IC50s = 68 and 60 nM, respectively). Dietary administration of anagliptin (0.05 and 0.3% w/w) decreases plasma DPP-4 activity, increases plasma GLP-1 levels, suppresses food intake and body weight gain, ameliorates insulin resistance, and improves glucose tolerance in wild-type and glucokinase knockout mouse models of high-fat diet-induced diabetes.{64685} It decreases hepatic lipid and M1 macrophage accumulation and prevents hepatic fibrosis and steatohepatitis in mice fed a high-cholesterol high-fat diet or a choline-deficient L-amino acid-defined, high-fat (CDAHF) diet.{64687} Anagliptin also reduces atherosclerotic lesion size in an Apoe-/- mouse model of atherosclerosis.{64686}
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