Formulation: A solid
Formal Name: 4-(5-fluoro-2-pyridinyl)-N-(4,5,6,7-tetrahydro-2-benzothiazolyl)-1-piperazineacetamide
Purity: ≥98%
Formula Markup: C18H22FN5OS
Formula Weight: 375,5
Shelf life (days): 1460
CAS Number: 1431945-95-7
Notes: Arylpiperazine 5k is an inhibitor of fatty acid transport protein 1 (FATP1; IC50 = 4.6 nM for the human protein).{67209} It reduces the accumulation of neutral and polar lipids in MDA-MB-231 breast cancer cells induced by linoleic acid (Item Nos. 90150 / 90150.1 / 21909) when used at a concentration of 12.5 µM.{68474} Arylpiperazine 5k (12.5 µM) decreases ATP (Item No. 14498) and BODIPY-palmitate (Item No. 26749) levels in BJAB human lymphoma cells with a deletion of CD37, which is also a negative regulator of fatty acid uptake, but not in wild-type BJAB cells.{69198} It induces cell death in MDA-MB-231, MCF-7, HCC1806, and BT474 human breast cancer cells when used at a concentration of 12.5 µM.
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